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Also, as discussed above and in the following sections, GPx-1 can regulate apoptogen-mediated signaling in apoptosis (404), alter the activation of NFκB (205, 224), and modulate Akt pathways (154, 351) to affect cellular proliferation and survival, suggesting that GPx-1 may have pleiotropic effects on apoptotic susceptibility

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A 2-year clinical study in 1991 used low-dose IM DFO (125 mg b.i.d., 5 days/week) in AD patients, which showed a significantly slower (∼50%) decline in daily living skills, suggesting a disease-slowing effect (Crapper McLachlan et al., 1991)